Invité par Sylviane Muller
Senior Assistant Professor
Department of Oral Rehabilitation and Regenerative Medicine,
Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
The therapeutic mechanism of mesenchymal stem cell transplantation in autoimmune diseases
Mesenchymal stem cells (MSCs) are a heterogeneous cell population, which can self-renew and can also differentiate into different lineages. They display important regulation roles in both adaptive and innate immune responses. Nowadays, MSCs are widely used in clinical trials as immunsuppressive agents for autoimmune and inflammatory diseases, including graft-versus-host disease, multiple sclerosis, systemic lupus erythematosus, chronic kidney diseases, and others.
Recent studies demonstrated that MSCs exert their immunomodulatory functions via secreting extracellular vesicles, which delivered parent cell cargo to recipient cells without oncogenicity or variability. It is also known that MSCs-induced immunotolerance involves soluble factors such as TGFbeta, IL-10 and others. At this stage, however, the detailed mechanisms that support MSCs immunomodulatory functions are not fully understood. In this lecture, Dr. Akiyama will show his findings with a focus on the therapeutic mechanisms exerted by MSCs through T cell apoptosis.