Publications

Paulen A, Hoegy F, Roche B, Schalk IJ, Mislin GLA (2017). Synthesis of conjugates between oxazolidinone antibiotics and a pyochelin analogue. Bioorg Med Chem Lett 27:4867-4870.

Schalk IJ, Mislin GLA (2017). Bacterial Iron Uptake Pathways: Gates for the Import of Bactericide Compounds. J Med Chem 60:4573-4576.

Ganne G, Brillet K, Basta B, Roche B, Hoegy F, Gasser V, Schalk IJ (2017). Iron Release from the Siderophore Pyoverdine in Pseudomonas aeruginosa Involves Three New Actors: FpvC, FpvG, and FpvH. ACS Chem Biol 12:1056-1065.

Molina L, Geoffroy VA, Segura A, Udaondo Z, Ramos JL (2016). Iron uptake analysis in a set of clinical isolates of Pseudomonas putida. Front Microbiol 7:2100.

Cunrath O, Geoffroy VA, Schalk IJ (2016). Metallome of Pseudomonas aeruginosa : a role for siderophores. Environ Microbiol 18:3258-3267.

Gasser V, Baco E, Cunrath O, August PS, Perraud Q, Zill N, Schleberger C, Schmidt A, Paulen A, Bumann D, Mislin GL, Schalk IJ (2016). Catechol siderophores repress the pyochelin pathway and activate the enterobactin pathway in Pseudomonas aeruginosa : an opportunity for siderophore-antibiotic conjugates development. Environ Microbiol 18:819-32.

Catekl-Ferreira M, Marti S, Guillon L, Jara L, Coadou G, Molle V, Bouffartigues E, Bou G, Schalk I, Jouenne T, Vila-Farrés X, Dé E (2016). The outer membrane porin OmpW of Acinetobacter baumannii is involved in iron uptake and colistin binding. FEBS Lett 590: 224-31.

Schalk IJ, Cunrath O (2016). An overview of the biological metal uptake pathways in Pseudomonas aeruginosa. Environ Microbiol 18:3227-3246.

Briard B, Bomme P, Lechner BE, Mislin GLA, Lair V, Prévost MC, Latgé JP, Haas H, Beauvais A (2015). Pseudomonas aeruginosa manipulates redox and iron homeostasis of its microbiota partner Aspergillus fumigatus via phenazines. Sci Rep 5:8220.

Cunrath O, Gasser V, Hoegy F, Reimmann C, Guillon L, Schalk IJ (2015). A cell biological view of the siderophore pyochelin iron uptake pathway in Pseudomonas aeruginosa. Environ Microbiol 17:171-185.

Ferret C, Cornu JY, Elhabiri M, Sterckeman T, Braud A, Jezequel K, Lollier M, Lebeau T, Schalk IJ, Geoffroy VA (2015). Effect of pyoverdine supply on cadmium and nickel complexation and phytoavailability in hydroponics. Environ Sci Pollut Res 22:2106-2116.

Gasser V, Guillon L, Cunrath O, Schalk IJ (2015). Cellular organization of siderophore biosynthesis in Pseudomonas aeruginosa : Evidence for siderosomes. J Inorg Biochem 148:27-34.

Paulen A, Gasser V, Hoegy F, Perraud Q, Pesset B, Schalk IJ, Mislin GL (2015). Synthesis and antibiotic activity of oxazolidinone–catechol conjugates against Pseudomonas aeruginosa. Org Biomol  Chem 13:11567-11579.

Vaulont S, Schalk I (2015). Roles of bacterial and mammalian siderophores in host-pathogen interactions. Med Sci 31:756-63.

Baco E, Hoegy F, Schalk IJ, Mislin GL (2014). Diphenyl-benzo[1,3]dioxole-4-carboxylic acid pentafluorophenyl ester : a convenient catechol precursor in the synthesis of siderophore vectors suitable for antibiotic Trojan horse strategies. Org Biomol Chem 12:749-757.

Cornu JY, Elhabiri M, Ferret C, Geoffroy VA, Jezequel K, Leva Y, Lollier M, Schalk IJ, Lebeau T (2014). Contrasting effects of pyoverdine on the phytoextraction of Cu and Cd in a calcareous soil. Chemosphere 103:212-219.

Ferret C, Sterckeman T, Cornu J-Y, Gangloff S, Schalk IJ, Geoffroy VA (2014). Siderophore promoted dissolution of smectite by fluorescent Pseudomonas. Environ Microbiol Reports 6:459-467.

Kizhakkepowathial KU, Prakasan P, Geoffroy VA, Doble M, Sailas B (2014). Pseudomonas aeruginosa BUP2- a novel strain isolated form Malabari goat produces type 2 pyoverdine. Advances in Bioscience and biotechnology 5:874-885.

Hoegy F, Mislin GLA, Schalk IJ (2014). Pyoverdine and pyochelin measurements. Methods Mol Biol 1149:293-301.

Hoegy F, Schalk IJ (2014). Monitoring iron uptake by siderophores. Methods Mol Biol 1149:337-346.

Maspoli A, Wenner N, Mislin GL, Reimmann C (2014). Functional analysis of pyochelin-/enantiopyochelin-related genes from a pathogenicity island of Pseudomonas aeruginosa strain PA14. Biometals 27:559-573.

Mislin GL, Schalk IJ (2014). Siderophore-dependent iron uptake systems as gates for antibiotic Trojan horse strategies against Pseudomonas aeruginosa. Metallomics 6:408-420.

Noël S, Hoegy F, Rivault F, Rognan D, Schalk IJ, Mislin GL (2014). Synthesis and biological properties of thiazole-analogues of pyochelin, a siderophore of Pseudomonas aeruginosa. Bioorg Med Chem Lett 24:132-135.

Unni KN, Priji P, Geoffroy VA, Doble M, Benjamin S (2014). Pseudomonas aeruginosa BUP2 - a novel strain isolated from Malabari goat produces type 2 pyoverdine. Adv Biosci Biotechnol 5:874-885.

Cornu JY, Elhabiri M, Ferret C, Geoffroy VA, Jezequel K, Leva Y, Lollier M, Schalk IJ, Lebeau T (2013). Contrasting effects of pyoverdine on the phytoextraction of Cu and Cd in a calcareous soil. Chemosphere 103:212-9.

Guillon L, Altenburger S, Graumann PL, Schalk IJ (2013). Deciphering Protein Dynamics of the Siderophore Pyoverdine Pathway in Pseudomonas aeruginosa. PLoS One 8:e79111.

Julou T, Mora T, Guillon L, Croquette V, Schalk IJ, Bensimon D, Desprat N (2013). Cell-cell contacts confine public goods diffusion inside Pseudomonas aeruginosa clonal microcolonies. Proc Natl Acad Sci U S A 31:12577-12582.

Schalk IJ, Guillon L (2013). Pyoverdine biosynthesis and secretion in Pseudomonas aeruginosa : implications for metal homeostasis. Environ Microbiol 15:1661-1673.

Schalk IJ (2013). Innovation and originality in the strategies developed by bacteria to get access to iron. Chembiochem 14:293-294.

Schalk IJ, Guillon L (2013). Fate of ferrisiderophores after import across bacterial outer membranes : different iron release strategies are observed in the cytoplasm or periplasm depending on the siderophore pathways. Amino Acids 5:1267-1277.

Brandel J, Humbert N, Elhabiri M, Schalk IJ, Mislin GL, Albrecht-Garry AM (2012). Pyochelin, a siderophore of Pseudomonas aeruginosa : Physicochemical characterization of the iron(III), copper(II) and zinc(II) complexes. Dalton Trans 41:2820-2834.

Brillet K, Ruffenach F, Adams H, Journet L, Gasser V, Hoegy F, Guillon L, Hannauer M, Page A, Schalk IJ (2012). An ABC Transporter with Two Periplasmic Binding Proteins Involved in Iron Acquisition in Pseudomonas aeruginosa. ACS Chem Biol 7:2036-2045.

Guillon L, El Mecherki M, Altenburger S, Graumann PL, Schalk IJ (2012). High cellular organization of pyoverdine biosynthesis in Pseudomonas aeruginosa : clustering of PvdA at the old cell pole. Environ Microbiol 14:1982-1994.

Hannauer M, Braud A, Hoegy F, Ronot P, Boos A, Schalk IJ (2012). The PvdRT-OpmQ efflux pump controls the metal selectivity of the iron uptake pathway mediated by the siderophore pyoverdine in Pseudomonas aeruginosa. Environ Microbiol 14:1696-1708.

Hannauer M, Schafer M, Hoegy F, Gizzi P, Wehrung P, Mislin GL, Budzikiewicz H, Schalk IJ (2012). Biosynthesis of the pyoverdine siderophore of Pseudomonas aeruginosa involves precursors with a myristic or a myristoleic acid chain. FEBS Lett 586:96-101.

Noël S, Rivault F, Schalk IJ, Mislin GLA (2012). Chimie des sidérophores : vers de nouvelles molécules pour une santé de fer ? Partie I. Stratégies innovantes pour la conception d'antibiotiques. Arch Sci Nat Phys Math NS 46:123-151.

Schalk IJ., Mislin GL, Brillet K (2012). Structure, Function and Binding Selectivity and Stereoselectivity of Siderophore–Iron Outer Membrane Transporters. Curr Top Membr 69:37-66.

Brillet K, Reimmann C, Mislin GL, Noël S, Rognan D, Schalk IJ, Cobessi D (2011). Pyochelin enantiomers and their outer-membrane siderophore transporters in fluorescent pseudomonads : structural bases for unique enantiospecific recognition. J Am Chem Soc 133:16503-9.

Nader M, Journet L, Meksem A, Guillon L, Schalk IJ (2011). Mechanism of ferripyoverdine uptake by Pseudomonas aeruginosa outer membrane transporter FpvA : no diffusion channel formed at any time during ferrisiderophore uptake. Biochemistry 50:2530–2540.

Noel S, Gasser V, Pesset B, Hoegy F, Rognan D, Schalk IJ, Mislin GL (2011). Synthesis and biological properties of conjugates between fluoroquinolones and a N3’’-functionalized pyochelin. Org Biomol Chem 9:8288-8300.

Noel S, Guillon L, Schalk IJ, Mislin GL (2011). Synthesis of fluorescent probes based on the pyochelin siderophore scaffold. Org Lett 13:844–847.

Rodriguez-Lucena D, Schalk IJ, Mislin GL (2011). Synthesis of gemini triethylene-tetramine bridged bis-tridentate iron(III) chelators. Tetrahedron 67:2149-2154.

Schalk IJ, Hannauer M, Braud A (2011). New roles for bacterial siderophores in metal transport and tolerance. Environ Microbiol 13:2844-54.

Yang B, Hoegy F, Mesini PJ, Mislin GL, Schalk IJ (2011). Terbium, a fluorescent probe for investigation of siderophore pyochelin interactions with its outer membrane transporter FptA. J Inorg Biochem 105:1293-1298.

Braud A, Geoffroy V, Hoegy F, Mislin GL, Schalk IJ (2010). Presence of the siderophores pyoverdine and pyochelin in the extracellular medium reduces toxic metal accumulation in Pseudomonas aeruginosa and increases bacterial metal tolerance. Environ Microbiol Rep 2:419–425.

Hannauer M, Barda Y, Mislin GL, Shanzer A, Schalk IJ (2010). The ferrichrome uptake pathway in Pseudomonas aeruginosa involves an iron release mechanism with acylation of the siderophore and a recycling of the modified desferrichrome. J Bacteriol 192:1212-20.

Hannauer M, Yeterian E, Martin LW, Lamont IL, Schalk IJ (2010). An efflux pump is involved in secretion of newly synthesized siderophore by Pseudomonas aeruginosa. FEBS Lett 584:4751-5.

Hoegy F, Gwynn MN, Schalk IJ (2010). Susceptibility of Pseudomonas aeruginosa to catechol-substituted cephalosporin is unrelated to the pyochelin-Fe transporter FptA.? Amino Acids 38:1627-9.

Rodriguez-Lucena D, Gaboriau F, Rivault F, Schalk IJ, Lescoat G, Mislin GL (2010). Synthesis and biological properties of iron chelators based on a bis-2-(2-hydroxy-phenyl)-thiazole-4-carboxamide or -thiocarboxamide (BHPTC) scaffold. Bioorg Med Chem 18:689-95.

Yétérian E, Martin LW, Guillon L, Journet L, Lamont IL, Schalk IJ (2010). Synthesis of the siderophore pyoverdine in Pseudomonas aeruginosa involves a periplasmic maturation. Amino Acids 38:1447-59.

Yétérian E, Martin LW, Lamont IL, Schalk IJ (2010). An efflux pump is required for siderophore recycling by Pseudomonas aeruginosa. Environ Microbiol Rep 2:412-8.

Braud A, Hannauer M, Mislin GL, Schalk IJ (2009). The Pseudomonas aeruginosa pyochelin-iron uptake pathway and its metal specificity. J Bacteriol 191:3517-25.

Braud A, Hoegy F, Jézéquel K, Lebeau K, Schalk IJ (2009). New insights into the metal specificity of the Pseudomonas aeruginosa pyoverdine–iron uptake pathway. Environ Microbiol 11:1079-91.

Greenwald J, Nader M, Célia H, Gruffaz C, Geoffroy V, Meyer JM, Schalk IJ, Pattus F (2009). FpvA bound to non-cognate pyoverdines : molecular basis of siderophore recognition by an iron transporter. Mol Microbiol 72:1246-59.

Hoegy F, Lee X, Noel S, Rognan D, Mislin GL, Reimmann C, Schalk IJ (2009). Stereospecificity of the siderophore pyochelin outer membrane transporters in fluorescent Pseudomonads. J Biol Chem 284:14949-57.

Schalk IJ, Lamont LA, Cobessi D (2009). Structure-function relationships in the bifunctional ferri-siderophore FpvA receptor from Pseudomonas aeruginosa. Biometals 22:671-8.

Aouad G, Crovisier JL, Damidot D, Stille P, Hutchens E, Mutterer J, Meyer JM, Geoffroy V (2008). Interaction between municipal solid waste incinerator bottom ash and Pseudomonas aeruginosa. Sci Total Environ 393:385-393.

Schalk IJ (2008). Metal trafficking via siderophores in Gram-negative bacteria : specificities and characteristics of the pyoverdine pathway. J Inorg Biochem 102:1159-69.

Greenwald J, Hoegy F, Nader M, Journet J, Mislin GL, Graumann PL, Schalk IJ (2007). Real time fluorescent resonance energy transfer visualization of ferric pyoverdine uptake in Pseudomonas aeruginosa. A role for ferrous iron. J Biol Chem 282:2987-95.

Nader M, Dobbelaere W, Vincent M, Journet L, Adams H, Cobessi D, Gallay J, Schalk IJ (2007). Identification of residues of FpvA involved in the different steps of the Pvd-Fe uptake in Pseudomonas aeruginosa. Biochemistry 46:11707-17.

Rivault F, Liébert C, Burger A, Hoegy F, Abdallah MA, Schalk IJ, Mislin GL (2007). Synthesis of pyochelin-norfloxacin conjugates. Bioorg Med Chem Lett 17:640-4.

Youard ZA, Mislin GL, Majcherczyk PA, Schalk IJ, Reimmann C (2007). Pseudomonas fluorescens CHA0 produces enantio-pyochelin, the optical antipode of the Pseudomonas aeruginosa siderophore pyochelin. J Biol Chem 282:35546-53.