Publications

Poirson J, Biquand E, Straub ML, Cassonnet P, Nominé Y, Jones L, van der Werf S, Travé G, Zanier K, Jacob Y, Demeret C, Masson M (2017). Mapping the interactome of HPV E6 and E7 oncoproteins with the ubiquitin-proteasome system. FEBS J 284(19):3171-3201.

Voith von Voithenberg L, Sánchez-Rico C, Kang HS, Madl T, Zanier K, Barth A, Warner LR, Sattler M, Lamb DC (2016). Recognition pf the 3’ splice site RNA by the U2AF heterodimer involves a dynamic population shift. Proc Natl Acad Sci USA 113:E7169-75.

Travé G, Zanier K (2016). HPV-mediated inactivation of tumor suppressor p53. Cell Cycle 15:2231-2.

Martinez-Zapien D, Ruiz FX, Poirson J, Mitschler A, Ramirez J, Forster A, Cousido-Siah A, Masson M, Vande Pol S, Podjarny A, Travé G, Zanier K (2016). Structure of the E6/E6AP/p53 complex required for HPV-mediated degradation of p53. Nature 529:541-545.

Vincentelli R* Luck K*, Poirson J, Polanowska J, Abdat J, Blémont M, Turchetto, J, Iv F, Ricquier K, Straub ML, Forster A, Cassonnet P, Borg JP, Jacob Y, Masson M, Nominé Y, Reboul J, Wolff N, Charbonnier S, Travé G (2015). High-throughput determination of domain-ligand affinities by automated holdup assay allows quantification of linear motif specificities. Nature Methods 12:787-793.

Stutz C, Reinz E, Honegger A, Bulkescher J, Schweizer J, Zanier K, Travé G, Lohrey C, Hoppe-Seyler K, Hoppe-Seyler F (2015). Intracellular analysis of the interaction between the Human Papillomavirus type 16 E6 oncoprotein and inhibitory peptides. Plos One 10:e0132339.

Ramirez J, Poirson J, Foltz C, Chebaro Y, Meyer A, Bonetta A, Jacob Y, Masson M, Deryckère F, Travé G (2015). Targeting the two oncogenic functional sites of HPV E6 oncoprotein with a high-affinity bivalent ligand. Angew Chem Int Ed Engl 54:7958-62.

Bonetta AC, Mailly L, Robinet E, Travé G, Masson M, Deryckere F (2015). Artificial microRNAs against the viral E6 protein provoke apoptosis in HPV positive cancer cells. Biochem Biophys Res Commun 465:658-664.

Tsakogiannis D, Gortsilas P, Kyriakopoulou Z, Ruether IG, Dimitriou TG, Orfanoudakis G, Markoulatos P (2015). Site of disruption within E1 and E2 genes of HPV16 and association with cervical dysplasia. J Med Virol 87:1973-80.

Zanier K, Stutz C, Kintscher S, Reinz E, Sehr P, Bulkescher J, Hoppe-Seyler K, Travé G, Hoppe-Seyler F (2014). The E6AP Binding Pocket of the HPV16 E6 Oncoprotein Provides a Docking Site for a Small Inhibitory Peptide Unrelated to E6AP, Indicating Druggability of E6. PLoS One 9:e112514.

Tsakogiannis D, Kyriakopoulou Z, Darmis F, Ruether IGA, Dimitriou TG, Orfanoudakis G, Panotopoulou E, Markoulatos P (2014). Prevalence o HPV16 E1-1374^63nt variants in Greek women. J Med Virol 86:778-84.

Zanier K, Charbonnier S, Ould M’hamed ould Sidi A, McEwen AG, Giovanna Ferrario M, Poussin-Courmontagne P, Cura V, Brimer N, Ould Babah K, Ansari T, Muller I, Stote RH, Cavarelli J, Vande Pol S, Travé G (2013). Structural basis for hijacking of cellular LxxLL motifs by papillomavirus E6 oncoproteins. Science 339:694-8.

Tsakogiannis D, Papadopoulou A, Kontostathi G, Ruether IGA, Kyriakopoulou Z, Dimitriou TG, Orfanoudakis G, Markoulatos P (2013). Molecular and evolutionary analysis of HPV16 E6 and E7 genes in Greek women. J Med Microbiol 62:1688-1696.

Zanier K, Ould M’hamed ould Sidi A, Boulade-Ladame C, Rybin V, Chappelle A, Atkinson A, Kieffer B, Travé G (2012). Solution structure analysis of HPV 16 E6 oncoprotein reveals a self-association mechanism required for E6-mediated degradation of p53. Structure 20:604-17.

Ould M’hamed Ould Sidi A, Ould Babah K, Brimer N, Nominé Y, Romier C, Kieffer B, Vande Pol S, Travé G, Zanier K (2011). Strategies for bacterial expression of protein-peptide complexes : Application to solubilization of papillomavirus E6. Protein Expr Purif 80:8-16.

Mackereth CD, Madl T, Bonnal S, Simon B, Zanier K, Gasch A, Rybin V, Valcarcel J, Sattler M (2011). Multi-domain conformational selection underlies pre-mRNA splicing regulation by U2AF. Nature 13:408-411.

Bernard X, Robinson P, Nominé Y, Masson M, Charbonnier S, Ramirez-Ramos JR, Deryckere F, Travé G, Orfanoudakis G (2011). Proteasomal degradation of p53 by human Papillomavirus E6 oncoprotein relies on the structural integrity of p53 core domain PLoS One 6:e25981.

Luck K, Fournane S, Kieffer B, Masson M, Nominé Y, Travé G (2011). Putting into practice domain-linear motif interaction predictions for exploration of protein networks. PloS One 6:e25376.          

Fournane S, Charbonnier S, Chapelle A, Kieffer B, Orfanoudakis G, Travé G, Masson M, Nominé Y (2011). Surface plasmon resonance analysis of the binding of high-risk mucosal HPV E6 oncoproteins to the PDZ1 domain of the tight junction protein MAGI-1. J Mol Recognition 24:511-523.

Zanier K, Ruhlmann C, Melin F, Masson M, Ould M'hamed Ould Sidi A, Bernard X, Fischer B, Brino L, Ristriani T, Rybin V, Baltzinger M, Vande Pol S, Hellwig P, Schultz P, Travé G (2010). E6 proteins from diverse papillomaviruses self-associate both in vitro and in vivo. J Mol Biol 396:90-104.

Ristriani T, Fournane S, Orfanoudakis G, Travé G, Masson M (2009). A single-codon mutation converts HPV16 E6 oncoprotein into a potential tumor suppressor, which induces p53-dependent senescence of HPV-positive HeLa cervical cancer cells. Oncogene 28:762-72.