Animal models are indispensable tools for advancing scientific research, enabling detailed exploration of fundamental biological processes, gene function, and development, as well as modeling a broad spectrum of physiological and pathological phenomena. These models provide essential in vivo data that drive innovation in fields such as genetics, developmental biology, immunology, and pharmacology. At the ICS (Institut Clinique de la Souris), our expertise in genome engineering supports the generation of customized mouse and rat models tailored to address a wide variety of research questions. We also offer versatile research tools, including reporter lines and Cre or CreERT2 mouse strains with either ubiquitous or targeted cell-type expression, to facilitate precise genetic studies and functional analyses.
The advent of CRISPR technology has revolutionized biomedical and basic research by enabling rapid, precise genome modifications—such as introducing point mutations, deletions, duplications, and inversions—across a variety of genomic contexts. CRISPR also allows for efficient insertion or replacement of large DNA segments, expanding the possibilities for generating complex models, studying gene regulation, and creating humanized lines for translational studies.
This presentation will showcase recent breakthroughs in generating genetically engineered animal models, emphasizing their contributions to a wide range of research applications and their role in expanding the frontiers of modern biological science.
Hosted by Dr. Ambre BENDER