PhD Theses defended

2024

  • 13 November 2024

Delphine BALARAMANE, Computational study of DNA methylation patterns and transcription factor binding in cancer (Supervisors: Michael Weber and Anaïs Bardet)

  • 4 October 2024

Mariam SAI, Fluoroprolines as a Tool to Probe Structural Ensembles and Interactions of Intrinsically Disordered Proteins (Supervisors : Vladimir Toorbev and Bruno Kieffer)

  • 27 September 2024

Thomas BACHELART, Structure-function studies of de novo designed protein catalysts for acyl-transfer reactions (Supervisor : Vladimir Toorbev)

  • 3 July 2024

Lisa ROEGEL, Rôle de PARP3 dans la mécanoréponse cellulaire de cellules cancéreuses (Supervisor : Françoise Dantzer)

  • 4 June 2024

Imane CHARMARKE ASKAR, From the identification of a molecular signature of multiple sclerosis to the identification of lumican as a therapeutic target for remyelination (Supervisor : Dominique Bagnard)

2023

  • 1 December 2023

Zuleyha YILDIRIM, PARP3 promotes myogenic differentiation and skeletal muscle function in cooperation with the histone methyltransferase EZH2 (Supervisor : Françoise Dantzer)

  • 22 November 2023

Céline DELAITRE, Pharmacological and functional characterization of angiotensin II AT1 receptor tracer ligands for the study of new therapeutic approaches (Supervisors : François Dupuis and Sandra Lecat)

  • 22 September 2023

Juliette KAEFFER, Involvement of GPRASP1 in the development of analgesic tolerance to delta-opioid receptor agonists (Supervisors : Sandra Lecat and Frédéric Simonin)

  • 18 September 2023

Thibaut HUBERT, Iron acquisition in 'Pseudomonas aeruginosa' : mathematical modelling of phenotypic switches (Supervisors : Isabelle Schalk and Morgan Madec)

  • 15 September 2023

Marion LEMARE, Use of microorganisms for the bioremediation of asbestos waste with mineral and organic matrices (Supervisor : Valérie Geoffroy)

  • 11 September 2023

Agathe BOOS, Relevance of PARP3 as a new therapeutic target in highly aggressive cancer cells and development of innovative antibody-drug conjugates to target PARP3 in these cells (Supervisor : Maria Zeniou-Meyer)

  • 20 June 2023

Hanna KRYNSKA, Characterisation of protein-protein interactions of the oncogenic isoform ΔNp73α (Supervisor : Katia Zanier)

  • 22 March 2023

Aline FAUCON, Vectorization of iridium(III) complexes using siderophores surrogates : a Trojan horse strategy using light against pathogenic bacteria (Supervisor : Gaëtan Mislin)

2022

  • 20 December 2022

Marion MOREL, Functional study of Dnmt3b and Dnmt3a with genetic models in mice (Supervisor : Michael Weber)

  • 5 October 2022

Thomas KUNTZEL, Systematic analysis of the transmembrane domain interactions : from the interleukine-10 and AMIGO3 receptor to all tyrosine kinase receptors (Supervisor : Dominique Bagnard)

  • 24 June 2022

Daisy HARWOOD, Towards a role of PARP3 in the transcriptional regulation of genes involved in tumour progression (Supervisor : Françoise Dantzer)

  • 21 June 2022

Dafni BIRMPILI, From the research for new therapeutic biomarkers of multiple sclerosis to the identification of apelin-13 as a drug candidate (Supervisor : Dominique Bagnard)

  • 6 April 2022

Stefano MORO, Characterization of protein-protein interactions mediated by the IKK complex (Supervisor : Katia Zanier)

  • 11 March 2022

Gwenaëlle GRAULIER, Study of role and evolution of siderophore production in interaction between Pseudomonas aeruginosa and different pathogens in cystic fibrosis (Supervisor : Pierre Fechter)

  • 4 March 2022

Sruthi VIJAYA RETNAKUMAR, Lysosomal autophagy in the treatment of inflammatory bowel disease (Supervisor : Sylviane Muller)

  • 28 January 2022

Lucile GUYOT, Evaluation of amphiphilic polymers for the extraction, purification and characterization of membrane proteins of therapeutic interest (Supervisor : Renaud Wagner)

2021

  • 17 Décember 2021

Lucas PHAM-VAN, Preclinical development of transmembrane domains targeting peptides in multiple sclerosis treatment (Supervisor : Dominique Bagnard)

  • 30 September 2021

Manon GERUM, Study of latent pain sensitization molecular and cellular mechanisms (Supervisor : Frédéric Simonin)

2020

  • 21 December 2020

Mykolas BENDORIUS, Le Rôle de l'autophagie dans le lupus neuropsychiatrique (Supervisor : Hélène Jeltsch-David)

  • 11 December 2020

Éric MOEGLIN, Targeting DNA damage response with nanobodies (Supervisor : Etienne Weiss)

  • 9 December 2020

Nadja GROYSBECK, Development of novel probes for high-resolution electron microscopy based on small-sized gold nanoparticle-antibody conjugates (Supervisor : Guy Zuber)

  • 23 September 2020

Anne BONNEAU, Molecular mechanism involved in iron acquisition by pyoverdin in Pseudomonas aeruginosa (Supervisor : Isabelle Schalk)

  • 18 September 2020

Leonel NGUEKEU ZEBAZE, Role of Poly(ADP-­‐Ribose) Polymerase PARP3 in glioblastoma tumorigenesis (Supervisors : Françoise Dantzer and Maria Zeniou-Meyer)

  • 11 September 2020

Jo-Ann NETTERSHEIM, Interplay between the translesion DNA polymerase η and the calpain system (Supervisor : Agnès Cordonnier)

  • 2 July 2020

Quentin PERRAUD, Molecular basis for antibiotic vectorization in order to overcome the low permeability of Pseudomonas aeruginosa membranes (Supervisors : Isabelle Schalk and Laurence Sabatier)

2019

  • 13 November 2019

Sébastien DAVID, Alteration of asbestos-containing waste by bacteria and siderophores for the development of a bioremediation process (Supervisor : Valérie Geoffroy)

  • 30 September 2019

Thomas DAHLET, DNA methylation : functions and recruitment during mouse development (Supervisor : Michael Weber).

  • 16 May 2019

Lucie HARTMANN, Development and characterization of immunological tools directed against membrane proteins of therapeutic interest (Supervisor : Renaud Wagner)

  • 9 April 2019

Frank DIETSCH, Characterization of PCNA’s post-translational modification functions using a new genetic tool (Supervisor : Bruno Chatton)

2018

  • 13 November 2018

Kathline MARTIN-HERNANDEZ, Role of Poly(ADP-Ribose) polymerase 3 (PARP3) in the differentiation of skeletal muscle stem cells in mice (Supervisor : Françoise Dantzer)

  • 19 September 2018

Andrea ARGÜESO LLEIDA, Development of approaches for targeted modifications of the methylome in mammalian cells (Supervisor : Michael Weber)

  • 12 April 2018

Armand DRIEU LA ROCHELLE, Functional interactions between RF-amide receptors and characterisation of mu opioid and NPFF receptors dual acting drugs (Supervisor : Frédéric Simonin)

  • 5 April 2018

Raphaëlle QUILLET, Identification and characterization of new selective pharmacological tools for the different RF-amides receptors (Supervisor : Frédéric Simonin)

  • 15 February 2018

Ana Yaiza CARBALLIDO LOPEZ, Role of pyoverdine and pyochelin siderophores in the homeostasis of biological metals different than iron in Pseudomonas aeruginosa (Supervisor : Isabelle Schalk)

2017

  • 11 December 2017

Éléa HÉBERLÉ, Role and regulation of the Poly(ADP-ribose)Glycohydrolase (PARG) in the cell response to DNA damages (Supervisor : Valérie Schreiber)

  • 23 November 2017

Ambre BENDER, DNA methylation and cellular identity : function of DNA methylation in gametic and hematopoietic lineages in mouse (Supervisor : Michaël Weber)

  • 20 November 2017

Safia AYACHI, Involvement of RF-amide peptide receptors in pain modulation and opioid induced hyperalgesia (Supervisor : Frédéric Simonin)

  • 7 April 2017

Aurélie PAULEN, Use of the Trojan horse strategy against Pseudomonas aeruginosa : syntheses and biological properties of siderophore-antibiotic conjugates (Supervisor : Gaëtan Mislin)

2016

  • 17 October 2016

Adeline GASSER, Discovery and cardioprotective effects of the first non-peptide agonists of the G protein-coupled prokineticin receptor-1 (Supervisor : Canan Nebigil)

  • 12 October 2016

Carole BECK, Molecular and cellular characterization of the role of the poly(ADP-ribose) polymerase 3 (PARP3) in the maintenance of genome integrity (Supervisor : Françoise Dantzer)

  • 22 September 2016

Juline POIRSON, HPV E6 and E7 oncoproteins interactome : from the ubiquitin-proteasome system to the Hippo signaling pathway (Supervisor : Murielle Masson)

  • 31 May 2016

Gilles SANSIG, Knockout mice for the metabotropic glutamate receptor mGluR7 reveal its role in cognition and emotions (Supervisor : Etienne Weiss)

2015

  • 22 October 2015

Ghislain AUCLAIR, Identification of targets and regulators of DNA methylation in mice (Supervisor : Michaël Weber)

  • 30 June 2015

Georgio KOURJIAN, Effect of HIV antiretroviral drugs on antigen processing and epitope presentation by MHC-I to cytotoxic T cells (Supervisor : Etienne Weiss)

  • 28 April 2015

Olivier CUNRATH, Metallome and iron homeostasie of Pseudomonas aeruginosa : a role for siderophores pyocheline and pyoverdine (Supervisor : Isabelle Schalk)

  • 29 September 2014

Alaa ABU-HELO, lnvolvement of GASP-1 in the modulation of the activity of beta2-adrenergic receptor agonists in the respiratory function (Supervisor : Frédéric Simonin)

  • 24 September 2014

Dayana ABBOUD, Role of chemokines in atopic diseases : pharmacological study using the neutraligands (Supervisor : Jean-Luc Galzi)

  • 24 June 2014

Étienne SCHAEFFER, Study of the protein ATF7 post-translational modifications (Supervisor : Bruno Chatton)

  • 20 May 2014

Aurore VILLEMIN, Generation of transgenic vectors encoding human immunoglobulins, functionality assays and transgenesis in mice (Supervisor : Étienne Weiss)

  • 14 March 2014

Mike DE VOS, Functional interaction between Poly(ADP-ribose) polymerase-1 (PARPl) and heterochromatin proteins : impact on heterochromatin function and DNA repair (Supervisor : Françoise Dantzer)

  • 31 January 2014

Guillaume FREUND, Antibodies and antibody fragments selection and characterization for intracellular immunotargeting (Supervisor : Étienne Weiss)

  • 27 November 2013

Christel LOGEZ, Study of human melatonine MT1 receptor by in vitro approaches : development of condition of production, purification and fonctional characterization (Supervisors : Renaud Wagner and Frédéric Simonin)

  • 26 September 2013

Thomas KALISCH, Biochemical and functionnal characterization of a new partner of poly(ADP-ribose) polymerase I : high-mobility group containing protein 2-like 1 (Supervisor : Valérie Schreiber)

  • 13 September 2013

Olivier BORNERT, Molecular and structural characterization of the GASP family of proteins (Supervisor : Frédéric Simonin)

  • 11 April 2013

Karl BRILLET, Structural and functionnal studies of proteins involved in iron uptake in Gram-negative bacteria (Supervisor : Claude Sauter)

  • 16 January 2013

Anaëlle BONETTA, Adenovirus mediated RNA interference as new therapeutic tool against cervical cancer (Supervisor : François Deryckère)

  • 19 October 2012

Katja LUCK, Towards a better understanding of protein interaction specificities in cell signalling - PDZ domains in the splotlight of computational and experimental approaches (Supervisor : Gilles Travé)

  • 27 September 2012

Bénédicte PESSET, Conception, synthesis and vectorization of potential inhibitors of the bacterial protein TonB (Supervisor : Gaëtan Misslin)

  • 26 September 2012

Cécilia SZATKOWSKI, Role of prokineticin-2 in adipose tissue (Supervisor : Canan Nebigil)

  • 21 September 2012

Khaled OULD BABAH, Biochemical and structural analysis of multiple interactions of the oncoprotein E6 produced by papillomavirus (Supervisor : Gilles Travé)

  • 20 September 2012

Christian BOEHLER, Roles of poly(ADP-ribose) polymerase-3 (PARP-3) in cellular response to DNA damage and in mitotic progression (Supervisor : Françoise Dantzer)

  • 19 September 2012

Claire FERRET, Role of fluorescent Pseudomonas in the biodisponibility of metals contamining the soil minerals : application to the phytoremediation (Supervisor : Valérie Geoffroy)

  • 18 September 2012

Mojdeh DORMISSIAN, Role of Prokineticin Receptor 1 in Endothelial Cells : in vivo study (Supervisor : Canan Nebigil)

  • 13 September 2012

Mounia BOULBERDAA, Role of prokineticin receptor 1 signaling pathways in heart and kidney function : implication of progenitor cells (Supervisor : Canan Nebigil)

  • 3 October 2011

Mélissa HANNAUER, Molecular mechanism involved in the iron acquisition via pyoverdine and desferrichrome in Pseudomonas aeruginosa (Supervisor : Isabelle Schalk)

  • 30 September 2011

Élise FOUQUEREL, Poly(ADP-Ribosyl)ation and genome integrity : role of Poly(ADP-Ribose) Glycohydrolase (PARG) in DNA repair and replication (Supervisor : Valérie Schreiber)

  • 23 September 2011

Kambiz NADERI, Contribution to the determination of the structure of subunit RPBII of human RNA polymerase II (Supervisor : Marc Vigneron)

  • 24 August 2011

Olivier HABRYLO, Characterization of three XEGIPs (xyloglucan-specific endoglucanase inhibitor proteins) from Humulus lupulus : inhibiting property against endoxylanases (glycosyl hydrolase family 12) and expression eliciting during physiological developpement and (a)biotic stresses (Supervisor : Vincent Phalip)

  • 26 November 2010

Jessica DIRING, Molecular mechanisms involved in the functional regulation of the ATF7 transcription factor (Supervisor : Bruno Chatton)

  • 22 November 2010

Xavier BERNARD, P53 stabilization and the role of human kinome in the HPV oncogenesis (Supervisor : Georges Orfanoudakis)

  • 12 November 2010

Sadek FOURNANE, Study of E6's oncogenic activities : interaction with PDZ-containing proteins and degradation of p53 protein (Supervisor : Georges Orfanoudakis)

  • 3 November 2010

Anne-Sophie RINALDI, Immunotargeting of gankyrin with human recombinant antibody fragments in intracellular context (Supervisors : Annie-Paule Sibler and Étienne Weiss)

  • 22 October 2010

Sabrina NOEL, Antibiotics vectorisation by siderophore and synthesis of potential inhibitors of the iron uptake pathway in Pseudomonas aeruginosa and Burkholderia cepacia (Supervisor : Gaëtan Mislin)

  • 7 July 2010

Ahmed MEKSEM, Structural and functional studies of TonB-dependent receptors of Gram-negative bacteria (Supervisor : Isabelle Schalk)

  • 1er July 2010

Valérie SCHMUTZ, Replication of damaged DNA in Eucaryotes : regulation and role of the mono-ubiquitinated PCNA (Supervisor : Agnès Cordonnier)

  • 17 June 2010

Émilie YÉTÉRIAN, Molecular basis of siderophore pyoverdine maturation and secretion in Pseudomonas aeruginosas (Supervisor : Isabelle Schalk)

  • 9 June 2010

Veronica ANDREOLI, Functional analysis of KLF6 transcription factor in the control of cell proliferation : interactions with cellular and viral oncoproteins (Supervisors : Bruno Chatton - Jose Luis BOCCO, Université de Cordoba, Argentine)